99.6% Anti-Epileptic Drug Pharmaceutical Intermediates Pregabalin Lyrica CAS 148553-50-8
Quick Detail:
Pregabalin
CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
Assay: 99%
Appearance: White Crystal Powder
Package: 25kg/drum
Usage: New antiepileptic drugs. Used in the treatment of peripheral neuropathy, or partial seizures
Description:
Pregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23.
Pregabalin is a white to off-white, crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is 1.35.
Application
1. Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by under the trade name.
2. Pregabalin is used to relieve neuropathic pain (pain from damaged nerves) that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes or in the area of your rash if you have had shingles (a painful rash that occurs after infection with herpes zoster).
3. It is also used to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep).
4. Pregabalin is used with other medications to treat certain types of seizures in people with epilepsy.
5. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body.
Efficiency:
Pregabalin belongs to a group of medicines known as anti-epileptic medicines, although it is prescribed for the treatment of several different conditions. You may have been prescribed it for the treatment of partial seizures, which is a type of epilepsy. A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. With a partial seizure, the burst of electrical activity stays in one part of the brain. Therefore, you tend to have localised or 'focal' symptoms. Pregabalin is also prescribed to treat certain types of long-lasting pain caused by damage to nerves. This type of pain, called neuropathic pain, can be caused by a number of different conditions, including diabetes (where it is called diabetic neuropathy) and shingles(where it is called postherpetic neuralgia).
Dosage of Pregabalin
1. LYRICA (pregabalin) oral solution, 20 mg/mL, is administered orally and is supplied as a clear, colorless solution contained in a 16 fluid ounce white HDPE bottle with a polyethylene-lined closure.
2. The oral solution contains 20 mg/mL of pregabalin, along with methylparaben, propylparaben, monobasic sodium phosphate anhydrous, dibasic sodium phosphate anhydrous, sucralose, artificial strawberry #11545 and purified water as inactive ingredients.
COA:
| Product name | Pregabalin | ||
| CAS No. | 148553-50-8 | Outer Packing | 25KG/Cardboard Drum |
| Production date | 2017.6.17 | Shelf life | 2 years |
| Standard adopted | company standard | ||
| Items of analysis | Specification | Results | |
| Loss on drying | ≤0.5% | 0.21% | |
| Specific Rotation | +10.0°~+13.0° | +10.8° | |
| Related Substances | Any single impurity ≤0.1% otal impurity ≤0.8% | 0.05% 0.10% | |
| Purity By HPLC R-isomer | ≤0.15% | 0.10 | |
| Residue on ignition | ≤0.1% | 0.05% | |
| Heavy metals | ≤10ppm | Complies | |
| Chlorides | ≤0.05% | Complies | |
| Assay | 98%~102.0% | 99.8% | |
| Conclusion | Qualified | ||
Packing:
Advantages:
Hongkong XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
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99.6% Anti-Epileptic Drug Pharmaceutical Intermediates Pregabalin Lyrica CAS 148553-50-8