Fosamax Bisphosphonate drug used for osteoporosis Alendronate Sodium Pharmaceutical raw Materials CAS:121268-17-5
Description:
Alendronate is a bisphosphonate drug used for osteoporosis and several other bone diseases. It is marketed alone as well as in combination with vitamin D.
Function
Alendronate inhibits osteoclast-mediated bone-resorption. Like all bisphosphonates, it is chemically related to inorganic pyrophosphate, the endogenous regulator of bone turnover. Whereas pyrophosphate and the first bisphosphonate, etidronate, are capable of inhibiting both osteoclastic bone resorption as well as the mineralization of the bone newly formed by osteoblasts, alendronate and the other potent N-containing bisphosphonates such as risedronate,ibandronate, and zoledronate specifically inhibit bone resorption without any effect on mineralization at pharmacalogically achievable doses. Its inhibition of bone-resorption is dose-dependent and approximately 1,000 times stronger than the equimolar effect of etidronate. Under therapy, normal bone tissue develops, and alendronate is deposited in the bone-matrix in pharmacologically inactive form. For optimal action, enough calcium and vitamin D are needed in the body in order to promote normal bone development. Hypocalcemia should, therefore, be corrected before starting therapy.
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Packing:
Q&A
Q1: How to confirm the Product Quality before placing orders?
A: By sending you our available samples.
Or if you have special requirement on the goods, we can prepare samples according to your requirement for your confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide some free sample, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: What's the MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 100g and 1kg.
Q4: How to place order and make payment?
A: You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by TradeManager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q5: How do you treat quality complaint?
A: All our products are strictly tested by our QC, and confirmed by QA; unqualified material will not be released to customer.
In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Detailed Product Information
Product Name :Alendronate sodium
Trade Name:Fosamax
CAS No.:121268-17-5
Molecular Formula: C4H12NO7P2.Na.3H2O
Molecular Weight:325.12g/mol
Purity : 99% HPLC
Appearance: White Powder
Typical use:Treatment of osteoporosis
Shelf Life :2 years
Payment Terms:T/T, Western Union, Money Gram
Storage:Room temperature keep dry and away from light.
Product Name :Alendronate sodium
Trade Name:Fosamax
CAS No.:121268-17-5
Molecular Formula: C4H12NO7P2.Na.3H2O
Molecular Weight:325.12g/mol
Purity : 99% HPLC
Appearance: White Powder
Typical use:Treatment of osteoporosis
Shelf Life :2 years
Payment Terms:T/T, Western Union, Money Gram
Storage:Room temperature keep dry and away from light.
Description:
Alendronate is a bisphosphonate drug used for osteoporosis and several other bone diseases. It is marketed alone as well as in combination with vitamin D.
Function
Alendronate inhibits osteoclast-mediated bone-resorption. Like all bisphosphonates, it is chemically related to inorganic pyrophosphate, the endogenous regulator of bone turnover. Whereas pyrophosphate and the first bisphosphonate, etidronate, are capable of inhibiting both osteoclastic bone resorption as well as the mineralization of the bone newly formed by osteoblasts, alendronate and the other potent N-containing bisphosphonates such as risedronate,ibandronate, and zoledronate specifically inhibit bone resorption without any effect on mineralization at pharmacalogically achievable doses. Its inhibition of bone-resorption is dose-dependent and approximately 1,000 times stronger than the equimolar effect of etidronate. Under therapy, normal bone tissue develops, and alendronate is deposited in the bone-matrix in pharmacologically inactive form. For optimal action, enough calcium and vitamin D are needed in the body in order to promote normal bone development. Hypocalcemia should, therefore, be corrected before starting therapy.
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| Product: | Alendronate Sodium |
| Chemical name : | 4-amidogen -1-hydroxy butyleneidene -1,1-diphosphonic acid single soduim salt |
| Molecular formula: | C4H12NaNO7P2 • 3H2O |
| Molecular weight: | 325.13 |
| CAS No.: | 121268-17-5 |
| Melting Points : | 245°C-257°C |
| Description: | White crystalline powder |
| Identification: | (1)physical chemistry reaction,positive reaction |
| (2) infrared absorption atlas in accord with the reference | |
| Acidity : | 4.2 ~ 4.6 |
| Chloride : | ≤ 0.01% |
| Lose on drying: | 16.0% - 17.5% |
| Sodium dihydrogen phosphite: | ≤ 0.3% |
| Total impurity: | ≤ 0.5% |
| Single impurity: | ≤ 0.1% |
| Heavy metal: | ≤ 10ppm |
| Assay: | ≥ 99.0% |
Packing:
- Delivery Time: Around 3-5 workdays after your payment.
- Package: In fiber-drums with two-plastic bags inside.
- Net Weight: 25kgs/Drum / Gross Weight: 28kgs/Drum
- Drum Size & Volume: I.D.42cm × H52cm, 0.08 m³/ Drum
- Storage: Stored in dry and cool place, keep away from strong light and heat.
- Shelf Life: Two years when properly stored.
- 1, DHL Express, FEDEX and EMS for quantity less than 50KG, usually called as DDU service;
- 2, Sea shipping for quantity over 500KG; and air shipping is available for 50KG above;
- 3, For high value products, please select air shipping and DHL express for safe;
- 4, Please confirm if you can make the clearance when goods reach your customs before placing an order, for buyers from Mexico, Turkey, Italy, Romania,Russia, and other remote area.
Q&A
Q1: How to confirm the Product Quality before placing orders?
A: By sending you our available samples.
Or if you have special requirement on the goods, we can prepare samples according to your requirement for your confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide some free sample, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: What's the MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 100g and 1kg.
Q4: How to place order and make payment?
A: You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by TradeManager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q5: How do you treat quality complaint?
A: All our products are strictly tested by our QC, and confirmed by QA; unqualified material will not be released to customer.
In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
